Research Articles (DO NOT USE)
Research Articles
Molecular Hydrogen has significant therapeutic potential for a wide range of disease models.
Recent progress toward hydrogen medicine: Potential of molecular hydrogen for preventive and therapeutic applications
“H2 prevented the decline of the mitochondrial membrane potential. This suggested that H2 protected mitochondria from OH. Along with this protective effect, H2 also prevented a decrease in the cellular level of ATP synthesized in mitochondria. The fact that H2 protected mitochondria and nuclear DNA provided evidence that H2 penetrated most membranes and diffused into organelles.”
H2 combats aging with its antioxidant and anti-inflammatory properties. Molecular hydrogen works as a “selective” antioxidant; i.e. it only attacks and neutralizes harmful free radicals, leaving beneficial free radicals alone to do their jobs. The toxic free radicals that H2 neutralizes are the primary source of premature aging.
Hydrogen-saturated saline protects intensive narrow band noise-induced hearing loss in guinea pigs through an antioxidant effect
“Our findings suggest that hydrogen-saturated saline is effective in preventing intensive narrow band noise-induced hearing loss through the antioxidant effect.”
Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury
“Molecular hydrogen given in drinking water reverses many of the sequelae of controlled cortical impact and suggests that it could be an easily administered, highly effective treatment for traumatic brain injury.”
Protective effect of saturated hydrogen saline against blue light-induced retinal damage in rats
“Saturated hydrogen saline could protect the retina from light-induced damage by attenuating oxidative stress.”
Hydrogen as a selective antioxidant: A review of clinical and experimental studies
“H2 is emerging as a novel and safe therapeutic antioxidant. It has selective antioxidant properties, giving it anti-inflammatory properties.”
Treatment with H2 appears to elevate brain-derived neurotropic factor, improving brain function. H2 treatment has also been shown to block pathological expression of tau proteins (i.e. neurofibrillary tangles, which are a central feature of Alzheimer’s disease). Additionally, H2 appears to combat neuroinflammation and oxidative stress.
Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury
“Molecular hydrogen given in drinking water reverses many of the sequelae of controlled cortical impact and suggests that it could be an easily administered, highly effective treatment for traumatic brain injury.”
Hydrogen as a selective antioxidant: A review of clinical and experimental studies
“H2 is emerging as a novel and safe therapeutic antioxidant. It has selective antioxidant properties, giving it anti-inflammatory properties.”
Oxidative stress and epididymal sperm transport, motility and morphological defects
“Radical oxidative species (ROS) have an important effect on sperm quality and quantity. High levels of CP can be measured in iOAT patients, indicating that OS could underlie the aetipopathogenesis of the syndrome. OS negatively affects flagellar axonemal structure with subsequent impairment of forward progressive sperm motility. This can put an attention for antioxidants as a therapy for iOAT syndrome and further research to find how to decrease ROS production.”
Effect of oxidative stress in male infertility
“Oxidative stress is involved with many chronic pathological conditions and the current study was designed to evaluate any association that may exist between male infertility and oxidative stress. Infertile male patients show an elevation of oxidative stress markers both in the erythrocytes and in the seminal plasma. Indicating that male infertility might be associated with increased oxidative stress.”
Naher, Z., Ali, M., Biswas, S., Mollah, F., Fatima, P., Hossain, M., & Arslan, M. (2013). Effect of oxidative stress in male infertility. Mymensingh Medical Journal, 22(1), 136-142.Retrieved from http://europepmc.org/abstract/med/23416821
Oxidative status and serum prolidase activity in tubal ectopic pregnancy
“Total antioxidant capacity levels were lower in the ectopic pregnancy group than the healthy group (p < 0.018), whereas total oxidant status, oxidative stress index and prolidase activity were higher (p < 0.05). Ectopic pregnancy may be associated with increased serum prolidase activity and oxidative stress, and this association may help to provide a better understanding about the pathogenesis of ectopic pregnancy.”
Hilali, N., Aksoy, N., Vural, M., Camuzcuoglu, H., & Taskin, A. (2013). Oxidative status and serum prolidase activity in tubal ectopic pregnancy. Journal of the Pakistan Medical Association, 63(2), 169-172.Retrieved from http://www.jpma.org.pk/PdfDownload/3990.pdf
Oxidative stress damage as a detrimental factor in preterm birth pathology
“Normal term and spontaneous preterm births (PTB) are documented to be associated with oxidative stress (OS), and imbalances in the redox system (balance between pro- and antioxidant) have been reported in the maternal-fetal intrauterine compartments. We postulate that fetal cell senescence signals generated by OS damage are likely triggers for labor.”
Studies that also show potential benefits for patients with type 2 diabetes, high cholesterol, and elevated triglycerides are also promising for metabolic syndrome, since there are often related and share similar features.
Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance
“Supplementation with molecular hydrogen-rich water may have a beneficial role in the prevention of type 2 diabetes and insulin resistence by helping to stabilize blood sugar, which is a critical aspect of long-term weight loss.”
Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases
“Effects of molecular hydrogen on various diseases have been documented for 63 disease models and human diseases in the past four and a half years. Six human diseases have been studied to date: diabetes mellitus type 2, metabolic syndrome, hemodialysis, inflammatory and mitochondrial myopathies, brain stem infarction, and radiation-induced adverse effects.”
Multiple studies on mice and rats have shown that H2 can repair liver damage and reduce inflammation associated with liver disease. H2 was shown to suppress liver fibrosis, which is a universal consequence of chronic liver disease. In other studies, H2 relieved liver injury, mostly because of the abilities to activate the body’s antioxidant capabilities and to down regulate extracellular signal-regulated protein kinase activation.
Effects of oral intake of hydrogen water on liver fibrogenesis in mice
“Oral intake of hydrogen water significantly suppressed liver fibrogenesis in the carbon tetrachloride and thioacetamide models, but these effects were not seen in the bile duct ligation model. We conclude that hydrogen water protects hepatocytes from injury by scavenging hydroxyl radicals and thereby suppresses liver fibrogenesis in mice.”
H2’s antioxidant properties have been shown, in rat studies, to be effective at combatting the severity of contrast-induced acute kidney injury and renal injury.
Inhalation of hydrogen gas is beneficial for preventing contrast-induced acute kidney injury in rats
“Mechanistic analyses showed that inhalation of H2 gas significantly reduced renal cell apoptosis, expression of cleaved caspase 3, and expression of an oxidative stress marker, 8-hydroxydeoxyguanosine, in injured kidneys. Results suggest that H2 gas inhalation is effective in ameliorating the severity of CIAKI in rats by reducing renal cell apoptosis and oxidative stress.”
